Using AAV-GLT1, we demonstrated that over-expression of GLT1 in rat parietotemporal cortex 3 weeks prior to MCAo reduced infarction caused by MCAo, improved neurological deficits, decreased the magnitude and duration of ischemia-induced glutamate overflow and attenuated ischemia-related TUNEL staining. This evidence concerns the gene SLC1A2 and infarction.