MC1R is located on chromosome 16 in the human genome flanked by Fanconi anemia, complementation group A (FANCA) and transcription factor 25 (TCF25) on one side, and differentially expressed in FDCP 8 (DEF8) and dysbindin (dystrobrevin binding protein 1) domain containing 1 (DBNDD1) on the other side in a 350 kb region (Figure S2). This evidence concerns the gene FANCA and anemia (phenotype).