Zhang et al. [17] also reported that there was a significant association between variants of CFHR2 and CFHR5 and AMD risk and showed that a haplotype spanning CFH (including the Y402H CFH variant), CFHR4, and CFHR2 was associated with the greatest risk of neovascular AMD (p<10−6). Here, CFHR4 is linked to age-related macular degeneration.