In a study of renal disease (with persistent microscopic hematuria, recurrent macroscopic hematuria, glomerulonephritis, and progressive renal failure), Gale et al. [41] found a rare internal duplication of exon 2 and exon 3 in CFHR5 that may account for the substantial proportion of renal disease in Cyprus and called it “CFHR5 nephropathy” [41]. This evidence concerns the gene CFHR5 and Hematuria.