A decreased level of gelsolin has been observed in patients with sepsis, myocardial infarction and inflammation while an increased level has been noted in amyloidosis [41,42], so it could be a secondary response to increased amyloid load The upregulation of these extracellular chaperones is likely a response to the increased oxidative stress in the aqueous secondary to glaucoma. Here, GSN is linked to glaucoma.