In contrast, the exposure of TfR-lytic hybrid peptide (10 μM) resulted in time-dependent loss of viability in these cells; a mere 10-min exposure of the TfR-lytic hybrid peptide to T47D, SKBR3, and BT20 cells was sufficient to kill more than 50% of cancer cells, and > 80% of cells lost viability after 60 min. Here, TFRC is linked to cancer.