The smallest of the VEGF isoforms, VEGF121 binds to two receptors designated VEGFR-1 (Flt-1/FLT-1) and VEGFR-2 (Flk-1/KDR), both of which are over-expressed on the endothelium of tumor vasculature but virtually undetectable in the vascular endothelium of adjacent normal tissues. This evidence concerns the gene KDR and neoplasm.