Amplification of the chromosomal region on 11q13 is frequently observed in human cancers including HNSCC and breast cancer, and it is well known that CCND1, encoding cyclin D1, is a putative oncogene in the 11q13 amplicon (Schuuring, 1995; Schwab, 1998; Gollin, 2001). This evidence concerns the gene CCND1 and head and neck squamous cell carcinoma.