Mechanisms of anti-tumour activity include direct MHC non-restricted killing of tumour cells, antibody-dependent cell-mediated cytotoxicity (ADCC) (Lanier et al, 1985; Braakman et al, 1992; Tokuyama et al, 2008) and indirectly through activation of other immune effectors. The gene discussed is HLA-C; the disease is neoplasm.