PTGS2 and neoplasm: Importantly, participants whose primary tumours overexpressed Cox-2 had most benefit with an HR of 0.39 (95% CI: 0.20–0.76) for colorectal cancer-specific mortality compared with an HR of 1.22 (95% CI: 0.36–4.18) for those whose primary tumours had weak or absent Cox-2 expression.