As a major function of IL-8 is to induce chemotaxis of cells expressing its receptors (CXCR1 and CXCR2) to sites of inflammation in the initial phases of an innate response (Mukaida, 2000), this data supports the potential for LAK/DC-derived IL-8 to sustain additional endogenous effector cell trafficking into targeted tumour sites in vivo. Here, CXCR1 is linked to neoplasm.