LTF and viral infectious disease: Toclarify the mechanism of this effect, the interaction of lactoferrin with RSV F protein, the mostimportant surface glycoprotein for viral penetration, was examined and results obtained showed thatlactoferrin directly interacted with the F (1) subunit, which involved antigenic sites of F protein [109].Concerning PIV, Lf exhibits antiviral activity against hPIV-2 by inhibiting virus adsorption to the surface of the cells thus preventing viral infection and replication [110].