However, the antiviral activity of lactoferrin detected in cultured cell monolayers infected by enveloped and naked viruses, has been found to be not related to the degrees of lactoferrin iron saturation, while Zn- and Mn-saturated lactoferrin exerted a potent antiviral capacity against HSV, HIV and poliovirus infection [61,83,125]. The gene discussed is LTF; the disease is poliovirus infection.