LTF and Rotavirus infection: Other studies investigated the role of metal binding, sialic acid and tryptic fragments of bLf in the activity towards rotavirus infection [119], Results obtained demonstrated that the effect of differently metal saturated lactoferrin was exerted during and after the viral attachment step, the removal of sialic acid enhanced the anti-rotavirus activity of lactoferrin, and that a large fragment (86–258) and a small peptide (324–329: YLTTLK) obtained by tryptic digestion of bLf were able to inhibit rotavirus even if at lower extent than undigested protein [119].