In this study, we have performed global miRNA expression profiling on eight well-characterized GEM models of human breast cancer (Table 1), including mouse mammary tumor virus (MMTV) long terminal repeat (LTR) promoter driven H-Ras [15], Her2/neu [16], c-Myc [17], polyoma middle T antigen (PymT) [18], and Wnt1 [19] transgenic mice; C3(1)/simian virus 40 (SV40) T/t-antigens (C3(1)/Tag) transgenic mice [20]; p53fl/fl ;MMTV-cre transplant model mice [21]; and BRCA1fl/fl;p53+/-;MMTV-cre mice [22]. This evidence concerns the gene MYC and breast cancer.