The vaginal ecosystem has to gradually adapt itself to the capability of keeping the balance between the candidiasis level just below the cut-off threshold, to avoid the unleash of the vulvovaginal allergic reaction, and the immunoregulating vaginal elements that are responsible of the inflammatory cascade (lymphokines, cytokines, MBL, vaginal epithelial cells, mast cells etc.). This evidence concerns the gene MBL2 and Candidiasis, Invasive.