Thus, the miR-17-92 cluster on chromosome 13, which contains six miRNAs (miR-17, -18a, -19a, -20a, -19b-1, and -92a-1), is amplified and overexpressed in B-cell lymphomas and solid tumors such as breast or small-cell lung cancers, where it may enhance oncogenesis by potentially targeting E2F1, p21/CDKN1A, and BCL2L11/BIM [49]. Here, BCL2L11 is linked to B-cell non-Hodgkin lymphoma.