GLS and neoplasm: The facts that GAM transcripts contain three consensus target sites for miR-663 and that GAM is sensible to resveratrol treatment (Tili et al., unpublished results) raises the question of the possible existence of a gene regulatory network that would allow miR-663 to impair GAM repressing activity on TGFβ1 signaling pathway when TGFβ1 works as a tumor suppressor, that is, at the early stages of tumorigenesis but not any more when this pathway starts to favor tumorigenesis and metastasis, that is, on advanced stages of cancers.