TGFB1 and neoplasm: In silico analysis using TargetScan showed that miRNAs downregulated by resveratrol in SW480 cells potentially target transcripts encoding known tumor suppressor factors, such as the two antiproliferation factors PDCD4 and PTEN, the components of the mismatch repair machinery MLH3, MSH2 and MSH3, DICER1, the RNase III producing mature miRNAs from their immediate precursors in the cytoplasm, and several effectors and regulators of the TGFβ signaling pathway [83].