SMAD3 and gastric cancer: For example, the targeting of both TGFβ1 and SMAD3 transcripts might possibly allow resveratrol to impair TGFβ1-induced SMAD3-dependent promotion of cell motility and invasiveness in advanced stages of gastric cancer [101, 102] or when SMAD2 and SMAD3 phosphorylated at both linker and COOH-terminal regions transmit malignant TGFβ1 signal in later stages of human CRC [103].