Extensive and nonextensive tumors with 4 cm as the limit were then further analyzed in a Cox proportional multivariate analyzes, controlling for grade of the invasive component, grade of the in situ component, size of the primary tumor (>15 mm or ≤15 mm), age, if the patient were treated with irradiation, whether or not the patient were given hormonal therapy, if the patient had chemotherapy or not, and whether the patient where positive or negative for estrogen receptor staining and progesterone receptor staining. This evidence concerns the gene ESR1 and neoplasm.