BCL2A1 and diffuse large B-cell lymphoma: In a study conducted by Brien et al. in B lymphoblastoid and diffuse large B-cell lymphoma cell lines, Bfl-1 silencing was found to potently induce apoptosis, and sensitize cells to rituximab-mediated cell death and apoptosis by doxorubicin, vincristine, cisplatin, or fludarabine [25].