In line with the gemcitabine-induced NF-κB activation, its target gene Bfl-1 was found to be markedly up-regulated, with little effect on the levels of other anti-apoptotic Bcl-2 proteins, including Bcl-2 and Bcl-xL; furthermore, this was observed in all NSCLC cell lines examined. This evidence concerns the gene BCL2 and non-small cell lung carcinoma.