As shown in Table 4, although we found no significant difference in the genotype and allele frequencies of the RPSA polymorphisms between controls and sporadic CJD groups, RPSA 793+58C>T showed a tendency to lower frequency of heterozygotes in sporadic CJD patients than those of controls (P = 0.058). Here, RPSA is linked to sporadic Creutzfeldt-Jakob disease.