Wu et al.[20] conducted a meta-analysis and reported that the combined RQ and QQ genotype of factor VII R353Q was correlated to a reduced risk for cardiovascular disease in 2,574 patients (OR 0.78, 95% CI 0.65 to 0.93), whereas the QQ genotype had offered more protection (OR 0.53, 95% CI 0.27 to 1.03). This evidence concerns the gene F7 and cardiovascular disorder.