Previous studies have examined the association of the three polymorphisms in the factor VII gene, including R353Q polymorphism, intron 7 polymorphism (HVR4:H5, H6 and H7 alleles), and -323 0/10 bp insertion/deletion polymorphism (allele A1 corresponds to the absence of the decamer (0) and allele A2 to its insertion 10), with the risk of CHD. The gene discussed is F7; the disease is coronary artery disorder.