The most common mutation associated with HGPS is a single base substitution in codon 608 of exon 11 on the LMNA gene resulting in the formation of a cryptic splice site that produces a truncated pre-lamin A protein called progerin, lacking 50 amino acids near the carboxyl terminus [6,13]. The gene discussed is LMNA; the disease is Hutchinson-Gilford progeria syndrome.