Although DSS did not produce statistically significant effect on the amelioration of diabetic-dependent alterations in urinary albumin, albumin excretion rate, and creatinine clearance, this classical formula can prevent or retard the development of diabetic nephropathy via its beneficial effects for correcting the hyperglycemia, antioxidant enzyme system, renal dysfunction and protecting against histopathological changes in the kidneys of diabetic rats which cannot be neglected. Here, ALB is linked to diabetic kidney disease.