ICAM1 and allergic asthma: This rolling phenomenon is a pre-requisite for the subsequent firm adhesion and transmigration, which is mediated by members of the integrin family, e.g. β2 integrins, and immunoglobulin gene superfamily, e.g. intercellular adhesion molecule-1 (ICAM-1) [18-20].Peribronchial inflammation contributes to the pathophysiology of allergic asthma.