SELE and asthma: We should keep in mind, however, that all three selectins co-operate at some level to influence eosinophil homeostasis, whereas P selectin is the only selectin whose absence impairs the recruitment of these cells to the inflamed peritoneum, the combined absence of P- and E-selectins seems to lead to the complete abrogation of the allergic response into the development of an asthma phenotype [34].