MAPT and Alzheimer disease: For example, most mutations of microtubule-associated protein tau (MAPT) that are associated with (frontotemporal dementia and Parkinsonism associated with chromosome 17 (FTDP17), a condition related to Alzheimer's disease, are translationally silent but increase splicing efficiency of exon 10 that increases the rate of inclusion through strengthening ESEs at the 5' end or weakening ESS at the 3' end [52].