One report has shown successful engraftment and HIV-1 infection in C57BL/10 Rag2-/-γc-/- mice engrafted with non-purified human fetal liver cells [64], although another report has shown an inability to achieve usable engraftment in the related C57BL/6 Rag2-/-γc-/- strain [34]. Here, RAG2 is linked to HIV-1 infection.