This study showed that IDR-1002 peptide suppressed IL-1β-induced inflammatory responses by altering the IL-1β-induced proteome, suppressed IL-1β-mediated activation of NF-κB, MAPK p38, and JNK, suppressed IL-1β-induced MMP-3 and MCP-1 production, but did not neutralize the production of all chemokines that are required for resolution of infections. Here, MMP3 is linked to infection.