Conversely, young rats with kaolin-induced hydrocephalus exhibited no changes in the endothelial transport molecules RAGE (receptor for advanced glycation end) or LRP-1 (low-density lipoprotein receptor-related protein) [27], while hydrocephalus in 12 month rats was associated with diminished LRP-1 immunoreactivity [28]. Here, LRP1 is linked to Hydrocephalus.