We also demonstrated that dietary fat increases the expression of proteins (Ki67, CDKs, and cyclins) involved in the regulation of cell-cycle progression as well as increases in the expression of CD31, VEGF, CD68, and CD45 in tumor tissues, thereby indicating that increases in immune cell infiltration and angiogenesis stimulate cell-cycle progression and the metastasis of tumor cells. The gene discussed is PECAM1; the disease is neoplasm.