In a study of skeletal muscle from cancer and AIDS patients suffering from cachexia, Ramamoorthy et al. analyzed the rectus abdominis and vastus lateralis muscles for the expression of TNFα, iNOS, and several proteins important for muscle differentiation and maintenance, including Jun-D, myogenin, myosin, and CKM (muscle creatine kinase). The gene discussed is NOS2; the disease is Cachexia.