APC and colonic neoplasm: A study of APCMin/+ mice—an established murine model for cancer cachexia in which a germline mutation in the adenomatous polyposis coli (APC) gene results in the development of colon cancer [60]—found a severe wasting of the gastrocnemius muscle that correlated with a 10-fold increase in circulating IL-6 levels when compared to wild-type mice [61].