Cost effectiveness analyses of the piloted indicators showed that only the myocardial infarction indicators could be linked directly to health gains, because there was clear clinical and economic evidence that recommended all patients presenting with an acute myocardial infarction should be treated, unless contraindications apply, with an ACE inhibitor, aspirin and beta-blockers indefinitely [26,27]. This evidence concerns the gene ACE and acute myocardial infarction.