Among the ninety-two patients who did not start HAART during acute HIV infection, 24 (26%, 95% CI: 17.5-36.3) patients presented with disease progression within the first year of infection: 12 had clinical progression (five AIDS-defining events and seven B events) and 12 exhibited immunological progression (CD4 cell count < 350 cells/mm3). Here, CD4 is linked to HIV infectious disease.