Potential insight into how DLL4-Notch signaling might function in colon cancer is provided by the fact that in normal colon development DLL4 is expressed on the paneth cells [39] which are adjacent to the stem cells and thought to play an important role as the niche to support stem cell maintenance and self-renewal through activation of Notch signaling. This evidence concerns the gene DLL4 and malignant colon neoplasm.