A subanalysis in an international randomized trial by the European Organization for Research and Treatment of Cancer/National Cancer Institute of Canada (EORTC/NCIC) compared the results of radiotherapy alone with those of concomitant radiotherapy and TMZ and showed that epigenetic silencing of the MGMT gene by promoter methylation increased the survival time of patients with primary GBM [3], [7]. This evidence concerns the gene MGMT and glioblastoma.