GHRL and invasive ductal breast carcinoma: qrtRT-PCR results showed that In1-ghrelin variant is expressed in normal mammary glands and, surprisingly, the expression levels of In1-ghrelin variant were found to be 8-fold up-regulated in a series of 40 sporadic invasive ductal breast carcinomas classified as high grade tumors (G3) compared with control samples (p = 0,0042) (Fig. 3A; table S4).