First, the minimal Epo concentrations needed to demonstrate Akt-phosphorylation (10 U/ml) in vitro were 1000-fold higher than normal blood concentrations in humans, ranging from 5 to 34 mU/ml [18], [31], [32], although we cannot exclude higher levels of Epo accumulating near tumor cells in tissues. Here, AKT1 is linked to neoplasm.