PDX1 and Glucose intolerance: In order to confirm that the glucose intolerance observed in Pdx1-Cre; Sox9+/flox versus Sox9+/flox control mice was not attributable to extraneous effects of the Pdx1-Cre transgene as reported in the RIP-Cre mouse line [28], we assayed glucose tolerance in Pdx1-Cre versus wild-type siblings on a Sox9+/+ background.