Recently, mutations in HOXA13 have been associated with Hand-Foot-Genital-(HFGS) and Guttmacher syndromes (GS), autosomal dominant disorders that profoundly affect limb and genitourinary development causing defects in the digits, carpal/tarsal bones, uterus, bladder, Mullerian ducts, and the external genitalia [2], [3], [4]. The gene discussed is HOXA13; the disease is hand-foot-genital syndrome.