Multiple sclerosis, an auto-immune disease that has been controversially reported as being possibly triggered by viral infections [50], is positively associated with HLA-A*02, C*08, DRB1*15, DQA1*01, and DQB1*06 [51], [52], whereas HLA-B*44 is reported to be protective [53]. This evidence concerns the gene HLA-DRB1 and viral infectious disease.