The additive effect between Raf and Mek inhibitors on CRaf PM translocation was observed when measuring CRaf/BRaf hetero-dimerization and CRaf kinase activation induced by GDC0879 in the KRasG12D/CRaf cells (Fig. 4d) as well as in H226 NSCLC cells where only endogenous proteins are expressed (Figure S8). Here, BRAF is linked to non-small cell lung carcinoma.