As shown in Figure 4A, the combination treatment of HCC cells with ABT-263 (1 μM) and YM-155 (1 μM) for up to 6 h has no effects on the expressions of either anti-apoptotic protein Bcl-xL or pro-apoptotic proteins including Bad, Bak, and Bax. This evidence concerns the gene BAK1 and hepatocellular carcinoma.