BIRC5 and hepatocellular carcinoma: In our study, with an attempt to understand the insensitivity of HCC cells to low dose of ABT-263-induced apoptosis, we found that another anti-apoptotic protein survivin is up-regulated in liver tumor tissues or cell lines, but rarely expressed in most normal tissues and undetectable in normal liver cells, suggesting that it may facilitate cell resistant to low doses of ABT-263 treatment.