The large body of data supporting the association of TGFB1 T29C and TGFBR1 6A/9A polymorphisms with the risk for breast cancer provides a strong basis to endorse the view that the combinations of genotypes resulting in weak TGF β signaling would have a greater impact on the risk for the disease - although the findings of epidemiological studies in this context remain equivocal [24], [25], [30]. The gene discussed is TGFBR1; the disease is breast cancer.