In contrast to mesenteric fat depots obtained from TNBS mice, we have observed that in comparison to MAT obtained from control subjects and Crohn's patients, creeping fat tissue obtained from Crohn's disease patients is characterized by an increased expression of IL-6, MCP-1 and leptin but has a reduced expression of PPARα, PPARγ and FXR. Here, IL6 is linked to Crohn disease.