Adiponectin may reduce LPS-induced NO production and nitrosative stress and prevent adventitial fibroblasts (AFs) from proliferating, transforming to myoflbroblasts, and migrating to the intima, thus worsening atherosclerosis, by inhibiting the AdipoR1-AMPK-iNOS pathway in AFs [19]. The gene discussed is ADIPOQ; the disease is atherosclerosis.