AKT1 and neoplasm: Of special interest, clinical trials combining MEK and PI3K/AKT/mTOR inhibitors are in an early stage of clinical development.[21] In addition, some preclinical experiments suggested that PI3K inhibition might reduce the migration and adhesion of tumor cells and consequently inhibit metastasis rather than the primary tumor, which may have important implications for treatment; however, these observations need to be confirmed in additional experiments.[22], [23]