Across tumor types, we demonstrated a higher prevalence of RAS (KRAS, NRAS) or BRAF mutations (47%) and KRAS mutations (38%) in patients with mutant PIK3CA compared to those with wtPIK3CA (mutant RAS or BRAF present in 24%, p = 0.001; mutant KRAS present in 16%, p = 0.001). The gene discussed is PIK3CA; the disease is neoplasm.