Although several preclinical studies suggest that aberrations in the PI3K/AKT/mTOR and the MAP kinase pathway may co-exist, only limited studies in patients have been undertaken, and have mostly concentrated on colorectal cancer.[8], [10], [11] We, therefore, investigated the PIK3CA, RAS (KRAS and NRAS) and BRAF mutation status of a large group of patients (N = 504) with advanced cancers referred to the Clinical Center for Targeted Therapy (CCTT) at The University of Texas MD Anderson Cancer Center (MD Anderson). This evidence concerns the gene PIK3CA and colorectal cancer.