PIK3CA and breast carcinoma: These data are similar to those previously published except for cervical cancer, which was shown to have a prevalence of PIK3CA mutations ranging from 8% (8/98) in the COSMIC database to 16% (2/12) published by Miyake et al.[29], [30] Colorectal and squamous cervical cancers were found to have a predominant E545K (exon 9) mutation (44%, 80%, respectively); uterine, ovarian, and breast cancers, a predominant H1047R (exon 20) mutation (57%, 43%, 67%, respectively); and squamous cell cancers of head and neck, an E542K (exon 9) mutation (40%).