PIK3CA and neoplasm: In regard to individual aberrations, oncogenic mutations in two hot spot regions (exons 9 and 20) of PIK3CA have been identified in various malignancies, including common tumors such as breast, lung, colorectal, ovarian and uterine.[11], [24], [25], [26], [27], [28], [29] In this study, PIK3CA mutations were identified in 11% of diverse tumor types.