Thirteen out of 19 genes in the heparan sulfate biosynthesis pathway had SNPs with p-value for marginal effect on BCC risk (PBCC)<0.05; the same was true for 14 out of 24 genes in the mCalpain pathway, 16 out of 32 genes in the Rho cell motility signaling pathway, and 16 out of 30 genes in the nitric oxide pathway. The gene discussed is CAPN2; the disease is skin basal cell carcinoma.