LGR5 and carcinoma: In one study [60], similar positivity for β-catenin and LGR5 (28% vs. 27%) was observed in adenomas, but not in carcinomas (54% positive for LGR5 vs. 81% positive for β-catenin), suggesting that in carcinomas the expression of LGR5 may become disconnected from canonical wnt signalling, or that excess stimulation of wnt signalling may lead to loss of LGR5.