Comparing two genetic mouse models of intestinal carcinogenesis, Lewis et al. [64] show highest LGR5 expression in tumours from APC(1322T) mice compared with APC(min) mice, with inverse correlation to β-catenin localization and the expression of wnt response genes, suggesting that LGR5 expression is stimulated within a relatively narrow range of wnt activation.[64]. This evidence concerns the gene LGR5 and neoplasm.