The clinical relevance of our findings are therefore, that the presence of abdominal obesity and/or cardio-metabolic risk factors including elevated insulin, low HDL, or low adiponectin in South Asian patients should prompt clinicians to assess the patient for the presence of fatty liver, and prescribe health behaviour changes and/or medical therapy to try and normalize their risk factor profile. The gene discussed is ADIPOQ; the disease is Abdominal obesity.