Three other loci in this chromosome region have been associated with autoantibody and/or autoimmune diseases: rs7528684, located in the promoter region of the FCRL3 gene, was associated with rheumatoid arthritis (RA) and SLE risk, as well as frequency of cyclic citrullinated peptide autoantibodies (CCPA) in Japanese RA patients [18]. This evidence concerns the gene FCRL3 and autoimmune disease.