Consistent with this general role in autoimmunity, six out of nine TPOA loci were associated with Graves' disease (except rs2069762 in IL2, rs3184504 in SH2B3 and rs7171171 in RASGRP, Table 5), including both newly identified Graves' disease loci BACH2 and UBASH3A. For these six TPOA/Graves' disease-associated SNPs, the Graves' disease risk allele is also the one associated with elevated frequency of TPOA. Here, SH2B3 is linked to Graves disease.