These associations, which are in opposite directions for IA-2A compared to the other autoimmune traits, contrast with the consistency observed for the PTPN22 and CTLA4 variants, for which the risk allele is consistently the same across multiple autoimmune diseases (in particular Graves' disease, T1D and TPOA in T1D patients, see Table 4). This evidence concerns the gene CTLA4 and autoimmune disease.