Further comparable to the TARDBP mutations identified in ALS cases, most of the FUS mutations cluster in the C-terminus of the FUS protein, including the most common mutations, R521C present in 22 FALS and 4 SALS and R521H present in 9 FALS and 4 SALS [11], [13], [14], [17]–[28]. Here, FUS is linked to amyotrophic lateral sclerosis.