AOAH and ulcerative colitis: These trans-eQTLs provide valuable insight on previously unknown functional downstream consequences trait-associated SNPs have, e.g. rs2395185 is the strongest susceptibility variant for ulcerative colitis [27] (UC) but also the strongest SNP, trans-acting on Acyloxyacyl hydrolase (AOAH, p = 1.0×10−36), an enzyme that modulates host inflammatory responses to gram-negative bacterial invasion.