The phenomenon of NK cell recognition and response to induced-self molecules has previously been implicated in both infections and oncogenesis[34], [35], [36], [37], where ligands MULT1[38], H60[39], and Rae-1[39], [40]) for the activating receptor NKG2D are preferentially induced upon infection or cellular transformation[36], [37], [41]. The gene discussed is RAE1; the disease is infection.