ADIPOQ and obesity due to melanocortin 4 receptor deficiency: The combination of the association of adiponectin with insulin resistance, support for an association of obesity with risk of colorectal cancer, and a previous report which found that adiponectin levels were inversely associated with risk of colorectal cancer suggest that the adiponectin pathway may contribute to colorectal carcinogenesis (Wei et al, 2005; Moghaddam et al, 2007; Vona-Davis et al, 2007; Fenton et al, 2008; Williams et al, 2008).